Intravital Microscopy

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Skin

Leveraging intravital imaging techniques, IVIM Technology empowers researchers to gain valuable insights into the dynamic processes occurring within the skin microenvironment in vivo. These insights lead to a deeper understanding of skin biology and facilitate the development of innovative therapeutic strategies for skin diseases and disorders. Here's how we can assist you.

Real-time In Vivo Imaging of Cellular-level Dynamic Phenotype Inside the Living Body

  • IVIM Technology’s contract R&D service provides high-quality observations of cellular-level dynamics in various animal models.
  • Dynamic 3D imaging of various cellular-level dynamics such as cell trafficking, cell-cell interaction, and cell-microenvironment interaction inside the living body in vivo will provide you a new insight in the processes of human disease development.

Skin

N⌀/M⌀

Inflammatory protein

skin

Cellular-level Dynamics in Various Tissues
In Vivo 4D cell imaging, tracking and interaction monitoring

  • Cell recruitment
  • Cell motility, motion of dendrite
  • Cell-Cell / Cell-Microenvironment interaction

Longitudinal In Vivo Imaging of Cellular-level Dynamic Phenotype Changes Inside the Living Body

  • IVIM Technology’s contract R&D service provides high-quality repetitive observations using imaging chambers.
  • Repetitive intravital imaging of cellular-level dynamics & tissue remodeling inside the living body in vivo will provide you a new insight in the processes of human disease development

Skin

Neutrophil

Vessel

Hair fcllicle

skin

Immune cell recruitment to irritated spo

  • Cell dynamics in irritated tissue after high-power laser irradiation
  • Wound-healing process at puncture
  • Cell dynamics at toxic chemical-induced injury site

In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues

IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.

BBB penetration & delivery to brain tissue•

Target disease : Neurodegenerative disease, Stroke, etc.

IVM Imaging for Skin Research

  1. Wound Healing Dynamics
  2. Hair Follicle Cycling
  3. Immune Cell Trafficking
  4. Microvasculature Imaging
  5. Tumor Microenvironment
  6. Drug Delivery and Efficacy
  7. Neuronal Interactions

Skin

Leveraging intravital imaging techniques, IVIM Technology empowers researchers to gain valuable insights into the dynamic processes occurring within the skin microenvironment in vivo. These insights lead to a deeper understanding of skin biology and facilitate the development of innovative therapeutic strategies for skin diseases and disorders.

Here's how we can assist you:

1. Wound Healing Dynamics

Intravital imaging allows for real-time visualization of wound healing processes, including inflammation, cell migration, angiogenesis, and tissue remodeling. Researchers can track the dynamics of immune cells, fibroblasts, and blood vessels during different stages of wound repair.

2. Hair Follicle Cycling

Intravital imaging enables the study of hair follicle dynamics, including hair growth cycles, stem cell activation, and follicle regeneration. Researchers can monitor the behavior of hair follicle stem cells and their interactions with neighboring cells within the skin microenvironment.

3. Immune Cell Trafficking

Intravital imaging facilitates the visualization of immune cell trafficking within the skin, including dendritic cells, macrophages, T cells, and mast cells. Researchers can investigate immune responses to infection, inflammation, and allergic reactions in real-time.

4. Microvasculature Imaging

Intravital imaging allows for the visualization of blood vessels and microcirculation within the skin, providing insights into vascular dynamics, perfusion, and angiogenesis. Researchers can study blood flow patterns, vessel permeability, and interactions between blood vessels and surrounding tissues.

5. Tumor Microenvironment

Intravital imaging of skin tumors, such as melanoma or squamous cell carcinoma, enables researchers to study tumor growth, invasion, and metastasis within the skin microenvironment. Researchers can monitor cancer cell behavior, immune cell infiltration, and therapeutic responses in vivo.

6. Drug Delivery and Efficacy

Intravital imaging can be used to assess the delivery and efficacy of topical or systemic drugs within the skin. Researchers can visualize drug distribution, penetration, and therapeutic effects in real-time, aiding in the development of novel dermatological treatments.

7. Neuronal Interactions

Intravital imaging allows for the study of neuronal interactions with the skin, including sensory nerve endings, neurovascular coupling, and neurogenic inflammation. Researchers can investigate the role of sensory nerves in skin physiology, pain perception, and neurocutaneous disorders.