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Intravital Microscopyの技術について

IVIMテクノロジーの革新的なオールインワン生体顕微鏡プラットフォームは、生体内における細胞の複雑かつ動的な挙動を観察できる中核的ソリューションです。この技術は、様々な人間の疾患における根本的な病態生理の解明と、新たな治療法の開発を可能にする最先端のコアテクノロジーです。

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製品紹介

  • IVM-C3

    IVM-C3

    Tractable, Fast, Gentle

    IVM-C3は、従来の蛍光顕微鏡と比べて検出効率、光学分解能、画像コントラストを大幅に向上させた高度に統合された共焦点専用生体顕微鏡システムです。

  • IVM-M3

    IVM-M3

    Deep Tissue Imaging, High-Resolution, Tunable

    IVM-M3は、波長可変型の柔軟な2光子顕微鏡であり、深部組織の観察に加え、SHG(Second Harmonic Generation)を利用することで、染色を行わずともコラーゲンや線維などの非線形構造を繰り返し観察することが可能なモデルです。

  • IVM-CM3

    IVM-CM3

    High Contrast, High Resolution, Dual-mode, Tunable

    IVM-CM3は共焦点と2光子の機能を統合したシステムであり、優れたSNR(信号対雑音比)と解像度を提供します。2光子観察のためのフェムト秒レーザーは、690nmから1050nmまでの波長変換が可能です。

  • IVM-MS3

    IVM-MS3

    Compact, Cost-Saving, Hands-Free

    IVM-MS3は、従来の2光子顕微鏡とは一線を画す、920nm固定式フェムト秒レーザーを搭載したオールインワン2光子生体顕微鏡システムで、非常に簡便かつ高性能です。

  • IVM-CMS3

    IVM-CMS3

    Cost-Effective, Straightforward, Dual-Mode

    IVM-CMS3は、市場で最もコンパクトかつリーズナブルな共焦点・2光子デュアルモードの生体顕微鏡です。簡単なボックス型のオールインワン構造で、生体顕微鏡に必要な機能がほぼすべて搭載されており、当社のベストセラーモデルです。

  • IVM-FS

    IVM-FS

    Practical, Customizable

    IVM-FSシステムは、IVM-CMS3と同様の機能を提供しながらも、大型ステージを備えたオープンタイプの生体顕微鏡です。生後6週以上のラットやフェレット、ウサギなどの大型動物にも対応可能です。

IVM-C3 (Confocal v.3)

IVM-C3 (Confocal v.3)

IVM-C3 is a highly integrated system for in vivo imaging, offering significantly enhanced detection efficiency, optical resolution, and image contrast compared to conventional fluorescence microscopy. With a 4-wavelength laser and four high-sensitivity confocal detectors, IVM-C3 enables multi-dimensional views of living cells and tissues in 3D or 4D, while supporting up to four different colors.

Key Features

Tractable Fast Gentle

Bone Marrow

Transplanted cell Vessel (CD31)

IVM-C3 (Confocal v.3)

Bone Marrow

Transplanted cell Vessel (CD31)

IVM-C3 (Confocal v.3)

Bone Marrow

Transplanted cell Vessel (CD31)

IVM-C3 (Confocal v.3)

IVM-M3 (Two-Photon v. 3)

DeepTissueImaging,High-resolution, Tunable

IVM-M3 (Two-Photon v. 3)

IVM-M3 seamlessly combines the flexibility of a traditional converted microscope with the high-resolution imaging capabilities of second-harmonic generation microscopy. Featuring a fully automated tunable fs-pulse NIR laser system, IVM-M3 excels in deep tissue imaging by using less-scattering NIR wavelengths. The comprehensive control functionality of the fs- laser system is integrated with the two-photon imaging software, ensuring user convenience with various automation algorithms. Experience advanced imaging with IVM-M3 for your research needs.

Key Features

Deep Tissue Imaging High-Resolution Tunable
IVM-M3 (Two-Photon v. 3)
IVM-M3 (Two-Photon v. 3)
IVM-C3

IVM-CM3 (ConfocalandTwo-Photon v. 3)

IVM-CM3 (ConfocalandTwo-Photon v. 3)

IVM-CM3 delivers exceptional contrast and resolution with its tunable Two-Photon laser unit.It allows focus on samples at desired wavelengths ranging from as low as 690 nm to as high as  1050 nm, and everything in between. This cutting-edge system seamlessly combines the strengths of both Confocal and Two-Photon microscopy, offering limitless possibilities for three- dimensional imaging of living cells whether near the skin or deep within tumors in small animals. Explore the potential of IVM-CM3 for advanced and versatile imaging in your research.

Key Features

High Contrast High Resolution Dual-mode Tunable

Liver

Fibrotic collagen Hepatocyte

IVM-CM3 (ConfocalandTwo-Photon v. 3)

Fibrotic collagen Hepatocyte

IVM-CM3 (ConfocalandTwo-Photon v. 3)

Fibrotic collagen Hepatocyte

IVM-CM3 (ConfocalandTwo-Photon v. 3)
IVM-M3

IVM-MS3 (Two- Photon Smart v.3)

IVM-MS3 (Two- Photon Smart v.3)

IVM-MS3 represents thesmart evolution of IVM-M3, an All-in-One Two-Photon Intravital Microscopy system meticulously optimized for in vivo imaging. This system seamlessly integrates a compact, high-stability, and maintenance-free fs-pulse laser unit into a single box. With the ability to focus on deep tissues at a fixed wavelength of 920nm, IVM- MS3 serves as an exceptional resource for researchers with specific targets, offering optimal functionality within limited resources and budget constraints. Explore the possibilities with IVM-MS3 for efficient and budget-friendly in vivo imaging.

Key Features

Compact Cost-Saving Hands-Free

Skin

Transplanted cell Transplanted cell Vessel (CD31)

IVM-MS3 (Two- Photon Smart v.3)

Large Intestine

Immune cell Mamnose (anti-inflammation) Blood vessel (EB)

IVM-MS3 (Two- Photon Smart v.3)

Kidney

H2B (Nuclei) ROSA-mT/mG Blood vessel (EB)

IVM-MS3 (Two- Photon Smart v.3)
IVM-CM3

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

IVM-CMS3 stands out as the world's most compact and affordable dual-mode intravital confocal and two-photon microscope, offering versatile functionality in a single, streamlined box. Leveraging the confocal laser units from IVM-C3 and the compact two-photon laser unit from IVM-MS3, IVM-CMS3 features a one-switch (one-click) mode changing capability, providing convenient multi-purpose use for intravital functional imaging while optimizing space and minimizing costs. Explore the efficient and cost-saving capabilities of IVM-CMS3 for your diverse imaging needs.

Key Features

Cost-Effective Straightforward Dual-Mode

Skin

CAG-RFP Collagen (SHG)

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

Liver

Collagen (SHG) Lipid Droplet (SF44)

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

Muscle

Sarcomere (SHG) Vessel (CD31) Nerve (Thy1)

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)
IVM-MS3

IVM-FS (Free-Space)

Practical, Customizable

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

The IVM-FS system offers the same functions as the IVM-CMS3 system, with the key difference being its larger stage and modules, designed to accommodate animals larger than mice and rats (older than 6 weeks), such as ferrets, rabbits, and others. With the dark curtain provided, there's no need for a dedicated dark room or specific space just for the microscope.

Key Features

Practical and Customizable - Tailored to Your Research Needs
IVM-CMS3

CROサービス

IVIMテクノロジーのCROサービスは、非臨床試験段階においてin vivoイメージングによる検証を通じ、薬剤の分布および有効性に関する直接的なデータを提供します。当社は単なるサービス提供にとどまらず、プロジェクトの成功を支える戦略的パートナーシップを提供し、研究開発の革新を支援します。

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cro

Events

  • Upcoming Webinar

    26 Jun 2025

    event demo

    (EN) From Antibody Therapeutics to ADCs: Imaging Analysis Using Intravital Microscopy

    Jenny Ohm
    Technical Application Scientist, IVIM Technology
    Learn more
  • Upcoming Webinar

    03 Jul 2025

    event demo

    (JP) 生体顕微鏡による脳疾患の経過と治療効果の 可視化 : 長期追跡研究への応用

    Learn more
  • Past Webinar

    19 Jun 2025

    event demo

    (KR) 항체치료제에서 ADC까지: Intravital microscopy을 활용한 이미징 분석

    Jenny Ohm
    Technical Application Scientist, IVIM Technology
    Learn more
  • Workshop

    06 Jan 2025

    event demo

    Real-time Confocal and Two-Photon Microscopy

    Learn more
  • Workshop

    27 Nov 2024

    event demo

    차세대 신약 개발 세미나

    Learn more
  • Workshop

    30 Oct 2024

    event demo

    AI/ 고급정밀 기술 기반 생체 내 기전 분석

    Learn more
  • Exhibition

    03 May 2025 - 07 May 2025

    event demo

    AAI 2025: American Association of Immunology

    Learn more
  • Exhibition

    25 Apr 2025 - 30 Apr 2025

    event demo

    AACR 2025: American Association of Cancer Research

    Learn more
  • Exhibition

    21 Jan 2025 - 23 Jan 2025

    event demo

    AIM 2025: Advanced Imaging Methods

    Learn more
  • Upcoming Webinar

    26 Jun 2025

    event demo

    (EN) From Antibody Therapeutics to ADCs: Imaging Analysis Using Intravital Microscopy

    Jenny Ohm
    Technical Application Scientist, IVIM Technology
    Learn more
  • Upcoming Webinar

    03 Jul 2025

    event demo

    (JP) 生体顕微鏡による脳疾患の経過と治療効果の 可視化 : 長期追跡研究への応用

    Learn more
  • Past Webinar

    19 Jun 2025

    event demo

    (KR) 항체치료제에서 ADC까지: Intravital microscopy을 활용한 이미징 분석

    Jenny Ohm
    Technical Application Scientist, IVIM Technology
    Learn more
  • Workshop

    06 Jan 2025

    event demo

    Real-time Confocal and Two-Photon Microscopy

    Learn more
  • Workshop

    27 Nov 2024

    event demo

    차세대 신약 개발 세미나

    Learn more
  • Workshop

    30 Oct 2024

    event demo

    AI/ 고급정밀 기술 기반 생체 내 기전 분석

    Learn more
  • Exhibition

    03 May 2025 - 07 May 2025

    event demo

    AAI 2025: American Association of Immunology

    Learn more
  • Exhibition

    25 Apr 2025 - 30 Apr 2025

    event demo

    AACR 2025: American Association of Cancer Research

    Learn more
  • Exhibition

    21 Jan 2025 - 23 Jan 2025

    event demo

    AIM 2025: Advanced Imaging Methods

    Learn more
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