Intravital Microscopyの技術について
IVIMテクノロジーの革新的なオールインワン生体顕微鏡プラットフォームは、生体内における細胞の複雑かつ動的な挙動を観察できる中核的ソリューションです。この技術は、様々な人間の疾患における根本的な病態生理の解明と、新たな治療法の開発を可能にする最先端のコアテクノロジーです。
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IVM-C3 (Confocal v.3)

IVM-C3 is a highly integrated system for in vivo imaging, offering significantly enhanced detection efficiency, optical resolution, and image contrast compared to conventional fluorescence microscopy. With a 4-wavelength laser and four high-sensitivity confocal detectors, IVM-C3 enables multi-dimensional views of living cells and tissues in 3D or 4D, while supporting up to four different colors.
Key Features
Bone Marrow
Transplanted cell Vessel (CD31)

Bone Marrow
Transplanted cell Vessel (CD31)

Bone Marrow
Transplanted cell Vessel (CD31)

IVM-M3 (Two-Photon v. 3)
DeepTissueImaging,High-resolution, Tunable

IVM-M3 seamlessly combines the flexibility of a traditional converted microscope with the high-resolution imaging capabilities of second-harmonic generation microscopy. Featuring a fully automated tunable fs-pulse NIR laser system, IVM-M3 excels in deep tissue imaging by using less-scattering NIR wavelengths. The comprehensive control functionality of the fs- laser system is integrated with the two-photon imaging software, ensuring user convenience with various automation algorithms. Experience advanced imaging with IVM-M3 for your research needs.
Key Features


IVM-CM3 (ConfocalandTwo-Photon v. 3)

IVM-CM3 delivers exceptional contrast and resolution with its tunable Two-Photon laser unit.It allows focus on samples at desired wavelengths ranging from as low as 690 nm to as high as 1050 nm, and everything in between. This cutting-edge system seamlessly combines the strengths of both Confocal and Two-Photon microscopy, offering limitless possibilities for three- dimensional imaging of living cells whether near the skin or deep within tumors in small animals. Explore the potential of IVM-CM3 for advanced and versatile imaging in your research.
Key Features
Liver
Fibrotic collagen Hepatocyte

Fibrotic collagen Hepatocyte

Fibrotic collagen Hepatocyte

IVM-MS3 (Two- Photon Smart v.3)

IVM-MS3 represents thesmart evolution of IVM-M3, an All-in-One Two-Photon Intravital Microscopy system meticulously optimized for in vivo imaging. This system seamlessly integrates a compact, high-stability, and maintenance-free fs-pulse laser unit into a single box. With the ability to focus on deep tissues at a fixed wavelength of 920nm, IVM- MS3 serves as an exceptional resource for researchers with specific targets, offering optimal functionality within limited resources and budget constraints. Explore the possibilities with IVM-MS3 for efficient and budget-friendly in vivo imaging.
Key Features
Skin
Transplanted cell Transplanted cell Vessel (CD31)

Large Intestine
Immune cell Mamnose (anti-inflammation) Blood vessel (EB)

Kidney
H2B (Nuclei) ROSA-mT/mG Blood vessel (EB)

IVM-CMS3 (Confocal and Two-Photon Smart v. 3)

IVM-CMS3 stands out as the world's most compact and affordable dual-mode intravital confocal and two-photon microscope, offering versatile functionality in a single, streamlined box. Leveraging the confocal laser units from IVM-C3 and the compact two-photon laser unit from IVM-MS3, IVM-CMS3 features a one-switch (one-click) mode changing capability, providing convenient multi-purpose use for intravital functional imaging while optimizing space and minimizing costs. Explore the efficient and cost-saving capabilities of IVM-CMS3 for your diverse imaging needs.
Key Features
Skin
CAG-RFP Collagen (SHG)

Liver
Collagen (SHG) Lipid Droplet (SF44)

Muscle
Sarcomere (SHG) Vessel (CD31) Nerve (Thy1)

IVM-FS (Free-Space)
Practical, Customizable

The IVM-FS system offers the same functions as the IVM-CMS3 system, with the key difference being its larger stage and modules, designed to accommodate animals larger than mice and rats (older than 6 weeks), such as ferrets, rabbits, and others. With the dark curtain provided, there's no need for a dedicated dark room or specific space just for the microscope.
Key Features
CROサービス
IVIMテクノロジーのCROサービスは、非臨床試験段階においてin vivoイメージングによる検証を通じ、薬剤の分布および有効性に関する直接的なデータを提供します。当社は単なるサービス提供にとどまらず、プロジェクトの成功を支える戦略的パートナーシップを提供し、研究開発の革新を支援します。
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