IVM-C3 is a highly integrated system for in vivo imaging, offering significantly enhanced detection efficiency, optical resolution, and image contrast compared to conventional fluorescence microscopy. With a 4-wavelength laser and four high-sensitivity confocal detectors, IVM-C3 enables multi-dimensional views of living cells and tissues in 3D or 4D, while supporting up to four different colors.

Key Features

IVM-M3 seamlessly combines the flexibility of a traditional converted microscope with the high-resolution imaging capabilities of second-harmonic generation microscopy. Featuring a fully automated tunable fs-pulse NIR laser system, IVM-M3 excels in deep tissue imaging by using less-scattering NIR wavelengths. The comprehensive control functionality of the fs- laser system is integrated with the two-photon imaging software, ensuring user convenience with various automation algorithms. Experience advanced imaging with IVM-M3 for your research needs.

Key Features

IVM-CM3 delivers exceptional contrast and resolution with its tunable Two-Photon laser unit.It allows focus on samples at desired wavelengths ranging from as low as 690 nm to as high as  1050 nm, and everything in between. This cutting-edge system seamlessly combines the strengths of both Confocal and Two-Photon microscopy, offering limitless possibilities for three- dimensional imaging of living cells whether near the skin or deep within tumors in small animals. Explore the potential of IVM-CM3 for advanced and versatile imaging in your research.

Key Features

IVM-MS3 represents thesmart evolution of IVM-M3, an All-in-One Two-Photon Intravital Microscopy system meticulously optimized for in vivo imaging. This system seamlessly integrates a compact, high-stability, and maintenance-free fs-pulse laser unit into a single box. With the ability to focus on deep tissues at a fixed wavelength of 920nm, IVM- MS3 serves as an exceptional resource for researchers with specific targets, offering optimal functionality within limited resources and budget constraints. Explore the possibilities with IVM-MS3 for efficient and budget-friendly in vivo imaging.

Key Features

IVM-CMS3 stands out as the world's most compact and affordable dual-mode intravital confocal and two-photon microscope, offering versatile functionality in a single, streamlined box. Leveraging the confocal laser units from IVM-C3 and the compact two-photon laser unit from IVM-MS3, IVM-CMS3 features a one-switch (one-click) mode changing capability, providing convenient multi-purpose use for intravital functional imaging while optimizing space and minimizing costs. Explore the efficient and cost-saving capabilities of IVM-CMS3 for your diverse imaging needs.

Key Features

The IVM-FS system offers the same functions as the IVM-CMS3 system, with the key difference being its larger stage and modules, designed to accommodate animals larger than mice and rats (older than 6 weeks), such as ferrets, rabbits, and others. With the dark curtain provided, there's no need for a dedicated dark room or specific space just for the microscope.

Key Features

Transforming Research Efficiency

Conventional denoising can take more than seven hours for a single dataset, slowing down research workflows and limiting the number of experiments that can be conducted.
AI-Image Denoiser reduces this process to just 30 minutes, enabling same-day analysis even for complex datasets. Beyond speed, the software preserves fluorescence without distortion, ensuring that fast-moving red blood cells or immune cells can be analyzed accurately. The result is not only higher efficiency but also improved reproducibility—researchers can trust that their quantitative measurements reflect true biological phenomena.

Applications in Advanced Imaging

• Tracking immune cell migration in inflamed tissues
• Monitoring rapid drug responses in vivo
• Measuring blood flow dynamics through red blood cell movement
• Long-term live imaging with reduced photobleaching

Specifications

Research Background

Traditional antigen-antibody labeling is limited in vivo due to dilution effects, handling errors, and signal loss. IVIM’s IVI Tag™ overcomes these barriers with advanced fluorescence tagging optimized for intravital microscopy. Researchers can now monitor vascular, immune, and neurological processes in real time without compromising signal integrity.

Research Benefits

• Reliable in vivo tracking of immune dynamics, vascular remodeling, and disease progression
• Longitudinal studies without repeated errors from traditional labeling
• High reproducibility and quantitative accuracy for preclinical and neuroscience models
• Easy integration into existing intravital microscopy workflows

Specifications

• Excitation/Emission Wavelengths: 406/445, 495/519, 554/565, 651/667 nm
• Compatibility: IVIM IVM systems, confocal, two-photon microscopes
• Product Range: Antibody panels for CD31, LYVE-1, CD11b, Ly6C, Gr-1, Ly6G, CD3, CD45, F4/80, CD206, GFAP, Tau, Amyloid β, Iba1, and more

DIY In Vivo Labeling Kits

The IVI Tag™ DIY In Vivo Labeling Kit enables researchers to fluorescently tag their own targets—including antibodies, exosomes, peptides, and chemical drugs—for precise in vivo imaging. Using IVIM’s conjugation technology, the kit simplifies the labeling process into a few straightforward steps, making it possible to generate high-quality in vivo labels within hours. Unlike traditional antigen-antibody conjugation methods, IVI Tag™ DIY ensures that fluorophores are expressed at the intended target sites in living tissues, reducing variability and signal loss. This flexibility allows scientists to customize their experiments and track novel biological processes in real time.

Research Background

Intravital microscopy enables visualization of biological processes in living organisms, but motion artifacts, limited access, and repeated surgeries restrict long-term and reproducible imaging.
Fixation adjuncts solve these issues by stabilizing organs and providing optical access windows, allowing researchers to conduct weeks of continuous observation without sacrificing animals after each session.

Core Technologies

Organ-Specific Windows

Dorsal skinfold, cranial, abdominal, mammary, pancreas, and uterus imaging chambers designed for precise access.

Dynamic Organ Stabilization

Tissue Motion Stabilizer (IVM-TMS) with micro-suction prevents micron-level tissue movement during imaging of the heart, lung, and thymus.

Motion Compensation Software

GPU-assisted algorithm corrects motion artifacts in real time, ensuring high-quality imaging of moving tissues.

Minimally Invasive Design

Lightweight, compact chambers reduce surgical burden and extend longitudinal studies.

Research Benefits

• Enables longitudinal imaging for several weeks
• Reduces animal use, promoting ethical research practices
• Provides stable platforms for drug delivery, cancer progression, immune dynamics, and vascular studies
• Enhances reproducibility and quantitative reliability in preclinical models

Applications Gallery

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  Lung

  Intravital in vivo applications in the lungs of mice provide a powerful tool for studying pulmonary biology, disease processes.

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  Heart

  In vivo intravital imaging of the heart in mice offers a powerful approach to studying dynamic cardiac processes and cardiovascular function.

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  Brain

  IVIM Technology provides advanced imaging solutions that support a wide range of intravital imaging applications in the brain.

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  Kidney

  In vivo intravital imaging of the kidney offers a powerful approach to studying dynamic cellular and molecular processes within this vital organ.

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  Pancreas

  Intravital in vivo applications in the pancreas offer a unique window into the dynamic processes underlying pancreatic physiology.

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  Liver

  In vivo intravital imaging of the liver offers a powerful approach to studying dynamic cellular and molecular processes within this vital organ.

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  Tumor

  In vivo intravital imaging of the tumor offers you the opportunity to explore various aspects of tumor biology through intravital imaging.

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  Skin

  Leveraging intravital imaging techniques, IVIM Technology empowers researchers to gain valuable insights into the dynamic processes occurring within the skin microenvironment in vivo.