Intravital Microscopy

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Brain

IVIM Technology provides advanced imaging solutions that support a wide range of intravital imaging applications in the brain. With our cutting-edge technology and expertise, we empower researchers to delve deep into the complexities of brain biology and pathology. With IVIM Technology, you will gain valuable insights into brain structure, function, and pathology, hence advancing our understanding of neurological disorders and informing the development of new treatments and therapies. Here's how IVIM Technology can support your brain intravital imaging needs:

Brain

Day 7

Vessel / BBB leakage

brain

Day 14

brain

Day 21

brain

Brain

Sham

Apoptotic body

Vessel

brain

Neuroinflammation

Apoptotic body

Vessel

brain
brain

Brain

Day 4

Neutrophil/Macrophage

Vessel

brain

Day 10

brain
brain

Longitudinal In Vivo Imaging of Cellular-level Dynamic Phenotype Changes Inside the Living Body

  • IVIM Technology’s contract R&D service provides high-quality repetitive observations using imaging chambers.
  • Repetitive intravital imaging of cellular-level dynamics & tissue remodeling inside the living body in vivo will provide you with new insight in the processes of human disease development.

Dynamic Changes in Brain Disease Models

  • Changes in BBB
  • penetrationChanges in target accumulation in brain tissue
  • Changes in cortical capillaries, vascular permeability & vessel diameter
  • Changes in pericyte coverage
  • Immune cell recruitment to inflammatory / damaged spot
  • Tissue cell apoptosis & phagocytosis

In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues

IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.

BBB penetration & delivery to brain tissue•

Target disease : Neurodegenerative disease, Stroke, etc.

Brain, Cortex

Control

BBB penetrating meterial

Vessel

brain

Drug

brain

Drug

brain

Brain, Cortex

Control

BBB penetrating meterial

brain

Drug

brain

Drug

brain
brain

IVM Imaging for Brain Research

  1. Neurovascular Interactions
  2. Microglial Dynamics
  3. Brain Development
  4. Neurodegenerative Diseases
  5. Brain Tumor Imaging
  6. Blood-Brain Barrier (BBB) Imaging
  7. Neuroimmune Interactions
  8. Drug Delivery and Efficacy

Brain

IVIM Technology provides advanced imaging solutions that support a wide range of intravital imaging applications in the brain. With our cutting-edge technology and expertise, we empower researchers to delve deep into the complexities of brain biology and pathology. With IVIM Technology, you will gain valuable insights into brain structure, function, and pathology, advancing our understanding of neurological disorders and informing the development of new treatments and therapies.

Here's how IVIM Technology can support your brain intravital imaging needs:

1. Neurovascular Interactions

Investigating interactions between neurons and blood vessels, including blood-brain barrier integrity, cerebral blood flow regulation, and neurovascular coupling.

2. Microglial Dynamics

Tracking microglial activation, motility, and interactions with neurons and other immune cells to understand their role in brain homeostasis, neuroinflammation, and neurodegenerative diseases.

3. Brain Development

Tracking neurodevelopmental processes such as neurogenesis, synaptogenesis, and myelination to comprehend how the brain develops and matures.

4. Neurodegenerative Diseases

Studying disease progression and pathogenesis in neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

5. Brain Tumor Imaging

Visualizing tumor growth, invasion, and response to therapy in brain tumors, including gliomas, metastases, and other malignancies.

6. Blood-Brain Barrier (BBB) Imaging

Assessing BBB integrity, permeability, and transport mechanisms to understand how the BBB regulates the passage of molecules and cells between the blood and brain.

7. Neuroimmune Interactions

Examining interactions between the nervous and immune systems in conditions like neuroinflammation, autoimmune diseases, and brain injuries.

8. Drug Delivery and Efficacy

Assessing the delivery, distribution, and therapeutic efficacy of drugs targeting the brain, including neuropharmaceuticals and drug delivery systems.