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Application: Drug Delivery Following Instillation Eye Drop

Abstract

The purpose of this experiment is to observe drug delivery to the cornea after the instillation of eye drops. The focus on biodistribution involves monitoring drug delivery over time following the instillation.

Therapeutic Target(s)

The treatment involves the instillation of eye drops to verify biodistribution by monitoring drug delivery over time. By assessing the precise drug distribution a few hours after instillation, the pharmacokinetic results of the drug can be predicted.

Mouse Model

The efficacy evaluation of instillation eye drops using the C57BL/6N mouse model is optimized for assessing the drug delivery after instillation the eye drops.

Experiment Design

Group #1 – Control

  • Dosing: 5uL/eye in PBS using 10uL pipette
  • Sample Size: N=3 /
  • Imaging method: IVM-FC (Free-space Confocal), 20X
  • Imaging time: 1 hr post eyedrops (additional scan at 2h or 3h in the same animal)

Group #2– Treatment

  • Dosing: 5uL/eye in PBS using 10uL pipette
  • Sample Size: N=3 /
  • Imaging method: IVM-FC (Free-space Confocal), 20X
  • Imaging time: 1 hr post eyedrops (additional scan at 2h or 3h in the same animal)

Duration

  • Total Time (Initiation to Completion): 3 weeks
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