Intravital Microscopy

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Eye

In vivo intravital imaging of the eye in mice offers a unique and powerful approach to studying ocular physiology, pathology, and therapeutic interventions. By leveraging IVIM Technology, researchers can gain valuable insights into the dynamic processes underlying ocular physiology and pathology, leading to the development of innovative diagnostic tools and therapeutic strategies for ocular diseases and conditions.

Real-time In Vivo Imaging of Cellular-level Dynamic Phenotype Inside the Living Body

  • IVIM Technology’s contract R&D service provides high-quality observations of cellular-level dynamics in various animal models.
  • Dynamic 3D imaging of various cellular-level dynamics such as cell trafficking, cell-cell interaction, and cell-microenvironment interaction inside the living body in vivo will provide you a new insight in the processes of human disease development.

Retina

RBC

Vessel

Intravascular Movement of Target Cells & Materials

  • In vivo real-time imaging of microcirculation• Microcirculation & dead space measurement
  • Functional capillary ratio measurement

Retina

DC/Monocyte

Cellular-level Dynamics in Various TissuesIn Vivo 4D cell imaging, tracking and interaction monitoring

  • Cell recruitment
  • Cell motility, motion of dendrite
  • Cell-Cell / Cell-Microenvironment interaction

In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues

IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.

Retina

Day 2

Gene

eye

Day 6

eye

Day 13

eye

Monitoring of Drug Delivery & Clearance in Target Tissues Delivery and clearance of fluorescently labeled novel therapeutic candidates

  • Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.

IVM Imaging for Eye Research

  1. Retinal Microvasculature Imaging
  2. Retinal Cell Dynamics
  3. Optical Coherence Tomography (OCT)
  4. Ocular Immune Responses
  5. Drug Delivery and Ocular Pharmacokinetics

Eye

In vivo intravital imaging of the eye in mice offers a unique and powerful approach to studying ocular physiology, pathology, and therapeutic interventions. By leveraging IVIM Technology, researchers can gain valuable insights into the dynamic processes underlying ocular physiology and pathology, leading to the development of innovative diagnostic tools and therapeutic strategies for ocular diseases and conditions.

Here are some key applications that IVIM Technology can support you with:

1. Retinal Microvasculature Imaging

Intravital imaging allows for the visualization of the retinal microvasculature, including arterioles, venules, and capillaries, providing insights into blood flow dynamics, vascular permeability, and microvascular function. With IVIM Technology, researchers can achieve high-resolution imaging of the retinal vasculature, facilitating the study of retinal vascular diseases such as diabetic retinopathy, retinal vein occlusion, and age-related macular degeneration.

2. Retinal Cell Dynamics

Advanced imaging techniques enable the direct observation of retinal cell dynamics, including photoreceptor activity, neuronal signaling, and glial cell behavior. IVIM Technology enhances imaging capabilities, allowing researchers to investigate the mechanisms of retinal degeneration, neuroinflammation, and synaptic remodeling in various retinal diseases and conditions.

3. Optical Coherence Tomography (OCT)

Intravital OCT imaging provides high-resolution, cross-sectional images of the retina, allowing for the quantification of retinal thickness, layer segmentation, and structural abnormalities. With IVIM Technology, researchers can conduct precise measurements and analyses of retinal architecture, edema, and neovascularization in diseases such as macular edema, retinal detachment, and choroidal neovascularization.

4. Ocular Immune Responses

Intravital imaging allows for the visualization of immune cell trafficking, activation, and interactions within the ocular tissues during inflammation, infection, and autoimmune diseases. With IVIM Technology, researchers can precisely track immune cells such as microglia, macrophages, and T cells, gaining insights into ocular inflammation, tissue damage, and repair mechanisms.

5. Drug Delivery and Ocular Pharmacokinetics

Intravital imaging can evaluate drug delivery, distribution, and therapeutic responses within the eye in real-time. IVIM Technology enables researchers to assess drug penetration, bioavailability, and efficacy in ocular tissues, guiding the development of novel therapies for retinal and ocular diseases.