IntraVital Microscopy

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Technology

IntraVital Microscopy (IVM)
In vivo cellular-level imaging platform

Conventional macro-scale image analysis & diagnosis
(Structural image information at the organ/organism level)

Micro-scale image analysis & diagnosis
(3D cellular image & molecule image)

IntraVital Microscope – Micro-scale In Vivo Imaging

  • New therapeutics manipulating in vivo micro-units, such as cell therapy, gene therapy, targeted molecular therapy is the core of future precision medicine and diagnosis.
  • IVIM Technology All-in-One IntraVital Microscopy is a state-of-the-art in vivo imaging platform capable of micro-scale cellular imaging optimized for precisely analyzing and diagnosing the pathophysiology of various human diseases and for testing the efficacy of new therapeutics in vivo.

  • IntraVital Microscopy (IVM) enables real-time imaging of various cellular level phenomena inside the living body, thus providing a new insight in the processes through which various diseases occur.
  • This enables scientists to directly verify a hypothesis based on data collected in ex vivo or artificial in vitro environments in an in vivo environment at the cellular level. It also enables real-time cellular level observation and analysis of dynamic phenomena in living tissues in vivo.
  • It is possible to directly analyze the delivery and efficacy of new therapeutic agents such as cell therapy agents, gene therapy agents, molecular target therapy agents, and biopharmaceutical agents in an in vivo environment.

IVIM Technology: All-in-One IntraVital Microscopy (IVM)

I Models I IVM-C (Confocal) / IVM-CM (Confocal & Two Photon)

    Key Feature
  • All-in-one system with a flexible design for modification and updates
  • Optimized for in vivo observation of mouse model for human diseases
  • Video-rate imaging (max. 100 fps - 512x512 pixels)
  • 4-color simultaneous confocal/two-photon imaging
  • Sub- µm in vivo imaging resolution
  • Key Application
  • In Vivo 4D cell imaging, tracking and monitoring
  • In Vivo visualization of dynamic molecular & cellular mechanisms
  • In Vivo efficacy monitoring of novel drug compound
  • In Vivo monitoring of material delivery target tissues
  • In Vivo real-time imaging of microcirculation
  • In vivo imaging of various organs in mouse model:
    - Liver, lymph node, spleen, skin, retina, lung, brain, colon, pancreas, small intestine, prostate, kidney, heart, trachea, esophagus, bone marrow, thymus, etc.
  • Image processing & analysis in cellular level:
    - Cell dynamics (cell movement, cell trafficking, cell motility, cell homing)
    - Cell-cell / cell-microenvironment / cell-molecule interaction
    - Cell death / survival, cell distribution, cell differentiation
  • Mouse model of various human disease :
    - Xenograft & syngeneic cancer model using fluorescent cancer cell lines (lung / breast / colon / pancreas cancer, glioblastoma, leukemia, melanoma, etc.)
    - Acute / chronic inflammation model (systemic injection, organ/tissue injury, ischemia-reperfusion injury)
    - Chimera model for intravital imaging of specific cell types (stem cell transplantation, adoptive cell transfer of lymphocyte, etc.)

Live Cell Intravital Imaging

  • In vivo cell dynamics imaging (cell trafficking, cell-cell interaction, cell activity)
  • In vivo time-lapse / mosaic imaging
- Lymph node

- Bone marrow

- Skin

Repetitive Intravital Imaging

  • Long-term repetitive imaging using implanted window chamber
  • Longitudinal cellular-level imaging (pathogenesis visualization)

Wide-area Intravital Imaging

  • In vivo cellular-level mosaic / three-dimensional imaging

In Vivo Small Intestinal Absorption Imaging

  • Real-time in vivo imaging of small intestine
  • Dynamic absorption monitoring in villi