In vivo Drug Efficacy Monitoring
In Vivo Monitoring of Drug Efficacy & Action
- • IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.
Therapeutic Candidates Facilitating or Inhibiting Angiogenesis
Vessel normalization by anti-angiogenic therapeutic candidates
- • Disease model : Tumor, acute/chronic inflammation, retinopathy, etc.
- • Therapeutic candidates : Anti-tumor, anti-inflammatory drug, etc.
- • Observations : Changes in vessel morphology, vessel diameter, vessel density, vascular permeability, blood flow rate, etc.
Tumor
Vehicle, Day 7
Vessel
Lung cancer cell

Vehicle, Day 13

Vehicle, Day 13

Tumor
Drug, Day 7
Vessel
Lung cancer cell

Drug, Day 13

Drug, Day 13



Angiogenesis in target cell transplanted site or ischemic regions
- • Disease model : Ischemia-reperfusion injury model, islet cell/stem cell transplantation model, etc.
Kidney
Vessel
Islet graft


Anti-inflammatory Therapeutic Candidates
Efficacy monitoring & MOA validation of anti-inflammatory therapeutic candidates
- • Disease model : Acute/chronic inflammation model, tumor model, etc.
- • Observations : Changes in microcirculation, tissue cell apoptosis, immune cell recruitment/motility/activity (phagocytosis), etc.
- • Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
- • Immune cells : Granulocyte, macrophage, neutrophil, dendritic cell, monocyte, microglial cell, NK cell, etc.
Pre-Drug
Neutrophil
RBC
Vessel

Post-Drug

Pre-Drug
RBC

Post-Drug

Quantitative comparison of groups
Lung
Sham
Merge

Neutrophil

RBC

Vessel

Vehicle
Merge

Neutrophil

RBC

Vessel

Drug
Merge

Neutrophil

RBC

Vessel




Efficacy Monitoring of Other Therapeutic Candidates
Changes in tumor cell growth/death/metastasis after treatment of anti-tumor therapeutic candidates
Changes in fibrotic collagen deposition & immune cell recruitment after treatment of anti-fibrotic therapeutic candidates
Changes in drug delivery, uptake & absorption
Changes in fibrotic collagen deposition & immune cell recruitment after treatment of anti-fibrotic therapeutic candidates
Changes in drug delivery, uptake & absorption