In vivo Drug Delivery Monitoring

In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues

IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.

Monitoring of Drug Delivery & Clearance in Target Tissues Delivery and clearance of fluorescently labeled novel therapeutic candidates

• Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.

Biodistribution of novel anti-tumor therapeutic candidates and commercial anti-tumor drugs in tumor and other tissues

• Target tissue : Primary tumor tissue, surrounding microenvironment, major site of tumor metastasis (lymph node, liver, lung, brain, etc.)
• Anti-tumor therapeutics : Cytotoxic drugs, anti-angiogenic drugs, etc.

Tumor

2 h

Neutrophil

Breast cancer cell

Vessel

6 h

24 h

Tumor

2 h

Nanoparticle

Vessel

6 h

24 h

Retinal delivery

• Administration route : Eyedrops, intravenous injection, intravitreal injection, etc.

Retina

Day 2

Gene

Day 6

Day 13

Sustained drug release from drug complex

• Drug complex types : Skin patch, transplantable complex, etc.

BBB penetration & delivery to brain tissue

• Target disease : Neurodegenerative disease, Stroke, etc.

Brain, Cortex

Control

BBB penetrating meterial

Vessel

Drug

Brain, Cortex

Control

BBB penetrating meterial

Drug

Cellular Uptake of Therapeutic Candidates Cellular uptake of new therapeutic candidates by target cells

• Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
• Immune cells : Macrophage, neutrophil, dendritic cell, monocyte, microglial cell, etc.

Liver

Liposomal ICG

Dendritric cell