In vivo Drug Delivery Monitoring
In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues
IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.
Monitoring of Drug Delivery & Clearance in Target Tissues
Delivery and clearance of fluorescently labeled novel therapeutic candidates
- • Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.
- • Target tissue : Primary tumor tissue, surrounding microenvironment, major site of tumor metastasis (lymph node, liver, lung, brain, etc.)
- • Anti-tumor therapeutics : Cytotoxic drugs, anti-angiogenic drugs, etc.
Tumor
2 h
Neutrophil
Breast cancer cell
Vessel

6 h

24 h

Tumor
2 h
Nanoparticle
Vessel

6 h

24 h

Retinal delivery
- • Administration route : Eyedrops, intravenous injection, intravitreal injection, etc.
Retina
Day 2
Gene

Day 6

Day 13

Sustained drug release from drug complex
- • Drug complex types : Skin patch, transplantable complex, etc.
BBB penetration & delivery to brain tissue
- • Target disease : Neurodegenerative disease, Stroke, etc.
Brain, Cortex
Control
BBB penetrating meterial
Vessel

Drug

Drug

Brain, Cortex
Control
BBB penetrating meterial

Drug

Drug


Cellular Uptake of Therapeutic Candidates
Cellular uptake of new therapeutic candidates by target cells
- • Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
- • Immune cells : Macrophage, neutrophil, dendritic cell, monocyte, microglial cell, etc.
Liver
Liposomal ICG
Dendritric cell

Liver
Liposomal ICG
Dendritric cell/Macrophage

Liver
Small vesicle
Microglial cell

Liver
0 min
Exosome
LysM
Ly6G

10 min

30 min

Real–time Intravital Imaging of Drug Delivery & Clearance in Metabolic & Digestive Organs
Drug delivery & clearance in metabolic organs
- • Target organs : Liver, kidney, lung, spleen, etc.
Liver
Nanoparticle
Dendritic cell
Liposomal drug
Dendritic cell/Macrophage

Small vesicle
Microglial cell

Liver
Liposomal ICG
33 sec
Liposomal ICG

294 sec



Drug infusion & absorption in digestive organs
- • Target organs : Small intestine, colon, etc.
Villi
Before
Fatty acid
Lymphatics

1 min

16 min

26 min

Mesentery
Before
Fatty acid
Lymphatics
Vessel

1 min

19 min

26 min
