In vivo Drug Delivery Monitoring
In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues
IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.
Monitoring of Drug Delivery & Clearance in Target Tissues
Delivery and clearance of fluorescently labeled novel therapeutic candidates
- • Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.
- • Target tissue : Primary tumor tissue, surrounding microenvironment, major site of tumor metastasis (lymph node, liver, lung, brain, etc.)
- • Anti-tumor therapeutics : Cytotoxic drugs, anti-angiogenic drugs, etc.
Tumor
2 h
Neutrophil
Breast cancer cell
Vessel
![](/assets/img/applications/a-86.jpg)
6 h
![](/assets/img/applications/a-87.jpg)
24 h
![](/assets/img/applications/a-88.jpg)
Tumor
2 h
Nanoparticle
Vessel
![](/assets/img/applications/a-89.jpg)
6 h
![](/assets/img/applications/a-90.jpg)
24 h
![](/assets/img/applications/a-91.jpg)
Retinal delivery
- • Administration route : Eyedrops, intravenous injection, intravitreal injection, etc.
Retina
Day 2
Gene
![](/assets/img/applications/a-92.jpg)
Day 6
![](/assets/img/applications/a-93.jpg)
Day 13
![](/assets/img/applications/a-94.jpg)
Sustained drug release from drug complex
- • Drug complex types : Skin patch, transplantable complex, etc.
BBB penetration & delivery to brain tissue
- • Target disease : Neurodegenerative disease, Stroke, etc.
Brain, Cortex
Control
BBB penetrating meterial
Vessel
![](/assets/img/applications/a-95.jpg)
Drug
![](/assets/img/applications/a-96.jpg)
Drug
![](/assets/img/applications/a-97.jpg)
Brain, Cortex
Control
BBB penetrating meterial
![](/assets/img/applications/a-98.jpg)
Drug
![](/assets/img/applications/a-99.jpg)
Drug
![](/assets/img/applications/a-100.jpg)
![](/assets/img/applications/a-101.jpg)
Cellular Uptake of Therapeutic Candidates
Cellular uptake of new therapeutic candidates by target cells
- • Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
- • Immune cells : Macrophage, neutrophil, dendritic cell, monocyte, microglial cell, etc.
Liver
Liposomal ICG
Dendritric cell
![](/assets/img/applications/a-102.jpg)
Liver
Liposomal ICG
Dendritric cell/Macrophage
![](/assets/img/applications/a-103.jpg)
Liver
Small vesicle
Microglial cell
![](/assets/img/applications/a-104.jpg)
Liver
0 min
Exosome
LysM
Ly6G
![](/assets/img/applications/a-105.jpg)
10 min
![](/assets/img/applications/a-106.jpg)
30 min
![](/assets/img/applications/a-107.jpg)
Real–time Intravital Imaging of Drug Delivery & Clearance in Metabolic & Digestive Organs
Drug delivery & clearance in metabolic organs
- • Target organs : Liver, kidney, lung, spleen, etc.
Liver
Nanoparticle
Dendritic cell
Liposomal drug
Dendritic cell/Macrophage
![](/assets/img/applications/a-109.jpg)
Small vesicle
Microglial cell
![](/assets/img/applications/a-110.jpg)
Liver
Liposomal ICG
33 sec
Liposomal ICG
![](/assets/img/applications/a-112.jpg)
294 sec
![](/assets/img/applications/a-113.jpg)
![](/assets/img/applications/a-114.jpg)
![](/assets/img/applications/a-115.jpg)
Drug infusion & absorption in digestive organs
- • Target organs : Small intestine, colon, etc.
Villi
Before
Fatty acid
Lymphatics
![](/assets/img/applications/a-116.jpg)
1 min
![](/assets/img/applications/a-117.jpg)
16 min
![](/assets/img/applications/a-118.jpg)
26 min
![](/assets/img/applications/a-119.jpg)
Mesentery
Before
Fatty acid
Lymphatics
Vessel
![](/assets/img/applications/a-120.jpg)
1 min
![](/assets/img/applications/a-121.jpg)
19 min
![](/assets/img/applications/a-122.jpg)
26 min
![](/assets/img/applications/a-123.jpg)