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(English) IVIM Technology Newsletter Vol.2
IVIM's recent news and applications for IntraVital Microscopy IVIM Technology Newsletter Vol.2 | SEPTEMBER 2021 IVIM Technology’s Newsletter provide our recent news and applications of IntraVital Microscopy Imaging. Application Note Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear- cytoplasmic labeling Bone marrow (BM) is soft and flexible tissue inside the bone, which houses hematopoietic stem/ progenitor cells (HSPCs) with multipotent differentiation capacity. With its vital role in maintaining homeostasis of circulatory/ immune system, bone marrow tra nsplantation (BMT) is actively utilized to treat patients with various hematologic disorders such as leukemia, anemia and multiple myeloma. However, current understanding about the underlying cellular mechanisms of transplanted HSPCs during early engraftme nt stage is relatively limited. In this work, we longitudinally visualized in vivo cellular behaviors of transplanted BM cells in host calvarial BM at subcellular level utilizing IVIM Intravital confocal microscopy system (IVM C, IVIM Technology). Notably, with a genetically engineered histone H2B GFP/β actin DsRed double transgenic mouse as a donor for the BMT, we achieved a subcellular level nuclear cytoplasmic morphological visualization of the transplanted BM cells in vivo delineating a dynamic cellular behaviors of cluster formation, migration, active proliferation, and differentiation into certain cell types in vivo. ( Published info.: PLoS ONE Vol. 12, Issue 11, e0187660 (2017)) Instrument IVM-C (Intravital Confocal Microscopy system) Full Text download Webinar/Hands-on, Brigham Women’s Hospital 8.23 - 25, The webinar about 'Intravital microscopy: In Vivo Live Cell Imaging Platform' and hands-on demo of IVM-MS2 have been made in a lab of Prof. Reza Abdi, director of Transplantation Research Center at Harvard Medical School, Brigham & Women's Hospital, Boston, USA. We appreciate Dr. Reza Abdi for this opportunity and all researchers who have participated the webinar. Installation IVM-MS2, Max Planck Institute 8.16, IVIM Technology's IntraVital Two-photon microscope system, the IVM-MS2, was installed in a lab of Prof. Ralf H. Adams, department of Tissue Morphogenesis at the Max Planck Institute for Molecular Biomedicine. We hope that various studies will be conducted through IntraVital Microscopy Imaging, and IVIM Technology will provide continuous support for this. Exhbition/Seminar Particitpation 6.15–17, Pharma R&D week 2021, Virtual 6.28–29, Nextrise, Seoul, Korea 7.14-16, KALAS, Jeju, Korea 7.21, IntraVital Microscopy Webinar #3, Virtual 7.27, KNTSC online seminar, Virtual 8.12-14, Korean Society for Stem Cell Research, Busan, Korea 8.26, IntraVital Microscopy Webinar #4, Virtual 9.21-23, TechCrunch Disrupt 2021, Virtual 10.14 IntraVital Microscopy Webinar(KOREAN) IVIM Technology appreciate Scintica, a U.S. and Canada business partner, have successfully completing full 4 series of IntraVital Microscopy webinar from May 20 to Aug 26. And many thanks to participants for enriching the webinars with interesting questions. IVIM Technology will constantly provide customized webinars and hands-on sessions online/offline. Our next webinar will be held on Oct.14 (Thu), 2pm. theme with '"All-in-One Intravital Microscopy : Live animal imaging system" (KOR) Registrate Webinar Are you interested in IVIM Technology's IntraVital Microscopy System? Click here and request hands-on demo / research service consultation. IVIM Technologyinformation@ivimtech.com #B-415, Daedeok BizCenter 17, Techno 4-ro, Yuseong-gu, Daejeon, 34013, Korea | +82-2-431-7450 Unsubscribe
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(Korean) IVIM Technology Newsletter Vol.2
IVIM Technology Newsletter Vol.2 | SEPTEMBER 2021 IVIM Technology는 뉴스레터를 통해 최신 소식 및 생체현미경 관련 어플리케이션을 자세히 소개해드립니다. Application Note Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear- cytoplasmic labeling 골수(Bone marrow)는 다분화 능력을 지닌 조혈 줄기 전구 세포(hematopoietic stem/progenitor cells (HSPCs))가 위치하고 있는 뼈 내부의 부드럽고 유연한 조직입니다. 골수는 순환계/면역계의 항상성을 유지하는 중요한 역할을 하여 골수 이식(Bone marrow transplantation(BMT))은 백혈병, 빈혈, 다발성 골수종과 같은 다양한 혈액 질환 환자의 치료에 적극적으로 활용되고 있습니다. 그러나 골수 이식의 의학적 응용의 중요성에도 불구하고 초기 생착 단계에서 이식된 HSPC를 포함하는 골수 세포의 시공간적 분포 및 생착의 세포 역학은 아직 완전히 파악되지 못한 상황입니다. 이번 연구에서는 IVIM 생체 내 이미징 시스템과 맞춤형 두개골 고정 시스템 및 H2B-GFP/β-actin-DsRed이중 형질 전환 마우스 모델을 이용하여 이식 골수세포의 증식 및 분화, 세포 클러스터 형성, 세포 이동의 양상을 영상화 하여 골수 이식 후 초기 생착의 생체 내 진행 경과를 시간에 따라 모니터링 했습니다. (Published info. : PLoS ONE Vol. 12, Issue 11, e0187660 (2017)) Instrument IVM-C (Intravital Confocal Microscopy system) 전문 다운로드 받기 Brigham Women’s Hospital 웨비나/핸즈온 데모 8월 23-25일, 미국 보스톤 하버드 의대 및 Brigham & Women's Hospital, Transplantation Research Center의 Director인 Reza Abdi 교수님 연구실에서 ‘Intravital microscopy: In Vivo Live Cell Imaging Platform’에 대한 웨비나와 IVM-MS2의 핸즈온 데모를 진행하였습니다. Dr. Reza Abdi에게 깊은 감사를 드리며, 참여해주신 모든 연구자분들께 감사드립니다. Max Planck Institute IVM-MS2 설치 8월 16일, 독일 Max Planck Institute for Molecular Medicine, Department of Tissue Morphogenesis, Ralf H. Adams 교수님 연구실에 아이빔테크놀로지의 IVM-MS2 장비가 설치되었습니다. 이제 독일에서도 세계 최소형 생체 이광자 현미경 IVM-MS2를 다양한 연구에 활용하실 수 있습니다. 학회 및 세미나 참가소식 아이빔테크놀로지는 다양한 학술행사를 통해 최신 연구동향을 살피고, 생체현미경을 이용한 다양한 어플리케이션을 전달하기위해 노력하고 있습니다. 6.15–17, Pharma R&D week 2021, Virtual 6.28–29, Nextrise, Seoul, Korea 7.14-16, 한국실험동물학회, Jeju, Korea 7.21, IntraVital Microscopy Webinar #3, Virtual 7.27, 한국비임상센터 온라인 세미나, Virtual 8.12-14, 한국줄기세포학회, Busan, Korea 8.26, IntraVital Microscopy Webinar #4, Virtual 9.21-23, TechCrunch Disrupt 2021, Virtual 10월 14일 IntraVital Microscopy 웨비나 개최안내 미국의 파트너사인 Scintica와 함께한 총 4번의 IntraVital Microscopy webinar 시리즈를 성공리에 마무리하였습니다. 다양한 질문으로 웨비나를 더욱 풍성하게 해주신 많은 참가자분들께 감사드립니다. 아이빔테크놀로지는 앞으로 국내 연구자들을 위한 맞춤형 웨비나 및 핸즈온세션을 온/오프라인으로 제공할 예정입니다. 10월 14일(목) 오후 2시, 생체 내 조직을 세포, 분자수준의 해상도로 이미징하는 생체현미경의 다양한 연구방향을 제시하는 웨비나에 여러분을 초대합니다. 참석하여 설문에 응해주시는 모든 분께, 스타벅스 아메리카노를 증정합니다. 웨비나 신청 바로가기 아이빔테크놀로지의 생체현미경 시스템에 관심있으신가요? 여기를 클릭하여 데모 및 서비스 상담을 신청하세요. 아이빔테크놀로지information@ivimtech.com대전광역시 유성구 테크노4로 17 대덕비즈센터 B-415 | 02-431-7450 수신거부 Unsubscribe
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(English) IVM-MS2, “The Most Compact All-in-One IntraVital Two-Photon Microscopy System in the World”.
IVIM Technology, Inc. has released the most compact all-in-one intravital two-photon microscope, "IVM-MS2". IVIM Technology, Inc. is the world's first start-up that commercializes all-in-one integrated intravital microscopy equipment. Our equipment uses innovative intravital microscopy (IVM) technology originally developed by KAIST.IVM-MS2 is the all-in-one IntraVital Two-Photon Microscopy System, optimized for in vivo imaging experiments and equipped with a new compact high-efficiency fs-pulse laser module. Especially, the IVM-MS2 is an ideal choice for customers with limited resources and budgets as it integrates a compact high-stability maintenance-free fs-pulse laser into a single box. The two-photon intravital microscope is in high demand for global leading advanced bioresearch institutes. And the newly released "IVM-MS2" will be installed at Harvard Medical School in the U.S.A. and Max Planck Institute in Germany."IVM-MS2" is designed to integrate all the functions necessary to image various processes in living animals with high cellular and molecular resolutions, allowing anyone not only equipment experts, to achieve the desired results without any difficulties. It is also equipped with imaging algorithms to automatically compensate movements such as heartbeats and lung movement caused by respiration based on its unique ultra-high speed in-vivo imaging (max. 100fps with 512x512 pixels), and a live animal maintenance system to maintain the physiological environment of tissues during image acquisition."IVM-MS2" is the first in the world to have an ultra-small 920nm ultra-fast fs-pulse laser module inside. The 920 nm wavelength is the most used wavelength in two-photon microscopy, it allows two photon-excitation of various fluorescent simultaneously and efficiently. Using “IVM-MS2” with high performance, high space-saving and reasonable price, researchers can observe various biological processes inside living animals without any limitation of fluorescence and get highly reliable results.In addition to 'IVM-MS2, IVIM Technology, Inc. has a variety of products lines including all-in-one confocal microscope 'IVM-C', multi-photon microscope ‘IVM-M’ and confocal/multi-photon microscope 'IVM-CM'. It also provides customized experimental services using customers’ own molecules or drug candidates by professional researchers in IVIM corporate research institute (All the researchers in IVIM lab are Ph. D from KAIST and have more than over 10 years of experiences).Recently, the biopharmaceutical industry has focused on developing new concepts of biopharmaceuticals, such as immunotherapy, cell therapy, gene therapy, and antibody therapy, rather than simply developing synthetic drugs. The human body works through complex interactions. However, in the preclinical stages of new drug development, studies have been conducted mainly in ways that do not involve interactions, such as in vitro and ex-vivo experiments. IVIM Technology's ultra-fast laser scanning three-dimensional intravital microscopy allows for direct observation of the cell movement inside living tissues, and individual cells moving inside various organs of the body that cannot be seen with MRI or CT. It also allows for imaging of various cells, molecules like proteins and surrounding microenvironments simultaneously with higher resolution and precision than that allowed by existing technologies. It allows getting detailed information about the process of various diseases occurring in the body in cellular level.IVIM Technology's intravital microscopy systems can be used for ▲In Vivo 4D cell imaging, tracking & monitoring, ▲In Vivo imaging of drug efficacy, and ▲In Vivo imaging of drug delivery. And you can get high-resolution intravital imaging of almost all tissues and organs, so it is perfect methods for accurate identification of drug mechanisms, especially for various new drug studies such as exosomes, bispecific antibodies, and microbiomes.
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