IntraVital Microscopy

Intravital microscopy enables dynamic 3D cellular-level imaging of various biological processes in living animals in vivo. It enables scientists to directly verify hypotheses derived from ex vivo or in vitro observations in natural physiological in vivo microenvironments.

Using intravital microscopy, in vivo visualizations of gene expression, protein activity, cell trafficking, cell-cell / cell-microenvironment interaction and various physiological responses to stimuli have been accomplished providing imperative novel insights, which have been impossible to obtain with Micro-scale static 2D observation of ex vivo or in vitro samples.

However, up to now, individual users have had to improvise the required functions for each of the intravital imaging applications for the various organs with conventional standalone microscope, which resulted in non-optimal imaging performance and limited applicability.

IVIM Technology’s All-in-One intravital microscopy system is extensively optimized and carefully engineered to provide superb performance in the intravital imaging of live animal models in vivo.

The world’s first All-in-One intravital microscopy platform from IVIM Technology is a key solution that can explore complex dynamic behaviors of numerous cells inside a living body and continuously serve as next generation core technology to elucidate unknown pathophysiology of various human diseases and discover new cures for them.

Conventional macro-scale image analysis & diagnosis

(Structural image information at the organ/organism level)

Micro-scale image analysis & diagnosis

(3D cellular image & molecule image)
IVIM Technology’s All-in-One intravital confocal/two-photon microscopy system (IVM-C/M/CM/MS2) is extensively optimized and carefully engineered to provide superb performance in the intravital imaging of live animal models in vivo.
Lymph Node

HEV (High Endothelial Venule)

T-cell
B-cell
FRC
Lung

Microcirculation in Sepsis Model

Neutrophil
Vessel flow
Bone Marrow

Transplanted BM cell, HSPC

BM cell
H2B
Sinus
Skin

Inflammatory response

KARS
Granulocyte
IntraVital Microscopy (IVM) enables dynamic 3D imaging of various cellular-level dynamics such as cell trafficking, cell-cell interaction and cell-microenvironment interaction inside the living body in vivo, providing a new insight in the processes of human disease development.
Cancer Xenograft

Triple Negative Human Breast Cancer

T cell
Cancer cell
Vessel
Cancer Metastasis

Cancer cell dissemination to circulation

Cancer cell
Stromal cell
Cancer Drug Delivery

Anti-cancer nanoparticle delivery

Drug carrier
Canver cell
Vessel
Drug Distribution

Real-time nanoparticle accumulation

Nanoparticle
Liver sinusold
For drug development, IVM enables a direct imaging analysis of the delivery to target tissue and cell, efficacy, and mode of action(MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.