In vivo Drug Delivery Monitoring

In Vivo Imaging of Drug Delivery & Clearance at Target Cells & Tissues

IVIM Technology’s contract R&D service provides a direct imaging analysis of delivery to target tissue and cells, efficacy, and mode of action (MOA) of new therapeutic candidates in microscopic cellular-level in various preclinical model of human disease.

Monitoring of Drug Delivery & Clearance in Target Tissues Delivery and clearance of fluorescently labeled novel therapeutic candidates
  • • Fluorescently labeled therapeutics : Antibody, protein, peptide, exosome, nanoparticle, cell, gene, plasmid, small molecules, etc.
Biodistribution of novel anti-tumor therapeutic candidates and commercial anti-tumor drugs in tumor and other tissues
  • • Target tissue : Primary tumor tissue, surrounding microenvironment, major site of tumor metastasis (lymph node, liver, lung, brain, etc.)
  • • Anti-tumor therapeutics : Cytotoxic drugs, anti-angiogenic drugs, etc.
Tumor
2 h
Neutrophil
Breast cancer cell
Vessel
6 h
24 h
Tumor
2 h
Nanoparticle
Vessel
6 h
24 h
Retinal delivery
  • • Administration route : Eyedrops, intravenous injection, intravitreal injection, etc.
Retina
Day 2
Gene
Day 6
Day 13
Sustained drug release from drug complex
  • • Drug complex types : Skin patch, transplantable complex, etc.
BBB penetration & delivery to brain tissue
  • • Target disease : Neurodegenerative disease, Stroke, etc.
Brain, Cortex
Control
BBB penetrating meterial
Vessel
Drug
Drug
Brain, Cortex
Control
BBB penetrating meterial
Drug
Drug
Cellular Uptake of Therapeutic Candidates Cellular uptake of new therapeutic candidates by target cells
  • • Tissue cells : Vascular endothelial cells, lymphatic endothelial cell, hepatocyte, kidney cell, astrocyte, etc.
  • • Immune cells : Macrophage, neutrophil, dendritic cell, monocyte, microglial cell, etc.
Liver
Liposomal ICG
Dendritric cell
Liver
Liposomal ICG
Dendritric cell/Macrophage
Liver
Small vesicle
Microglial cell
Liver
0 min
Exosome
LysM
Ly6G
10 min
30 min
Real–time Intravital Imaging of Drug Delivery & Clearance in Metabolic & Digestive Organs Drug delivery & clearance in metabolic organs
  • • Target organs : Liver, kidney, lung, spleen, etc.
Liver
Nanoparticle
Dendritic cell
Liposomal drug
Dendritic cell/Macrophage
Small vesicle
Microglial cell
33 sec
Liposomal ICG
294 sec
Drug infusion & absorption in digestive organs
  • • Target organs : Small intestine, colon, etc.
Villi
Before
Fatty acid
Lymphatics
1 min
16 min
26 min
Mesentery
Before
Fatty acid
Lymphatics
Vessel
1 min
19 min
26 min