Ex Vivo Imaging

Whole Tissue 3D Imaging of Tissue Sample, Ex Vivo

IVIM Technology’s contract R&D service provides a high-quality whole tissue 3D imaging from the surface into deep tissue including cell distribution, structural changes.

Deep Tissue Imaging with Tissue Clearing Technique Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues
  • • Primary tumor, metastasized tissues, etc.
Lymph Node
Normal
Neutrophil
Vessel
Metastasis - Day 10
Metastasis - Day 13
Primary Tumor
Vessel
Breast cancer cell
  • • Various tissues in chimeric model (Lymph node, kidney, etc.)
Lymph Node
Be cell zone
T cell
B cell
Vessel
T cell zone
3D
T cell
B cell
  • • Normal skin (hair follicle), tooth, lymph node, internal organs (liver, spleen, kidney), etc.
Skin
Basal cell
Actin
Nuclei
Sebaceous gland
Muscle & vessel
Tooth
Nonirritated
Vessel
Granulocyte
Autofluorescence
irritated
irritated
Validation of Drug Delivery & Action Delivery of therapeutic candidates and cosmetics into deep tissues
  • • Drug delivery to deep tissue (hair follicle, cortex, hippocampus, etc.)
  • • Transdermal delivery of cosmetic complex
Skin
Normal
Fluorophore
Modified #1
Modified #2
Whole Tissue 3D Imaging with Tissue Clearing Technique Imaging of cell distribution, structural changes (vessel, lymphatic, capsule) in optically cleared tissues
  • • Imaging various tissue obtained from normal & disease model
  • • Colormap by imaged depth